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5-Amino-1MQ
5-Amino-1MQ
$50.00
5-Amino-1MQ
Quantity
Description
5‑Amino‑1MQ is increasingly recognized as a promising tool in metabolic and longevity research. This small‑molecule compound functions as a potent inhibitor of the enzyme nicotinamide N‑methyltransferase (NNMT), a key regulator of cellular energy balance and fat metabolism. By blocking NNMT activity, 5‑Amino‑1MQ helps preserve NAD+ availability, thereby supporting mitochondrial function, energy production, and metabolic efficiency. Beyond its role in cellular energetics, 5‑Amino‑1MQ is being explored for potential benefits in insulin sensitivity, lipid regulation, and inflammatory control. The discovery that NNMT activity rises with age and metabolic stress has sparked intense scientific interest, positioning 5‑Amino‑1MQ as a candidate for supporting brain health, metabolic resilience, and extended healthspan.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 500mg, 1000mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Structural Properties
Stability: Sensitive to light and moisture
Solubility: Soluble in DMSO and ethanol
Storage Conditions: Store at 36‑46 °F (2‑8 °C)
Form: White crystalline powder
Biochemical Profile
Chemical Formula: C₁₀H₁₁N₃
Molecular Weight: 173.22 g/mol
CAS: 1604‑56‑2
Structure: Methylquinoline derivative
Biological Mechanism
5‑Amino‑1MQ serves as a pivotal controller of metabolic pathways, preserving NAD+ and enhancing mitochondrial function:
Key Mechanisms
NNMT Inhibition
Blocks nicotinamide N‑methyltransferase (NNMT), preserving intracellular NAD+ and SAMe levels.
NAD+ Preservation
Enhances mitochondrial function and cellular energy balance by maintaining NAD+ availability.
Methylation Modulation
Influences methylation pathways, impacting gene expression and metabolic regulation.
Metabolic Benefits
Fat Metabolism
Promotes lipolysis and reduces adipose accumulation, supporting body composition improvements.
Insulin Sensitivity
Enhances glucose uptake and metabolic flexibility, protecting against insulin resistance.
Inflammatory Control
Reduces pro‑inflammatory markers such as TNF‑α and IL‑6, improving immune signaling and metabolic stability.
Research Highlights
Research on 5‑Amino‑1MQ supplementation has highlighted its significant influence on metabolic health and aging processes:
Cellular Longevity
• Preservation of NAD+ levels
• Restoration of youthful cellular function
• Improved mitochondrial performance
• Reduced oxidative stress
• Lower cellular senescence
• Protection against age‑related decline
Genomic Integrity
• Enhanced DNA damage repair
• Reduced mutation accumulation
• Protection against methylation imbalance
• Improved genomic stability
• Potential anti‑tumor properties
Immune Modulation
• Improved T‑cell regulation
• Lower chronic inflammation
• Enhanced immune signaling
• Better response to metabolic stress
• Support for immune surveillance
Metabolic Optimization
• Enhanced insulin sensitivity
• Improved glucose metabolism
• Better lipid profiles
• Increased metabolic flexibility
• Protection against metabolic syndrome
• Reduced inflammatory markers
Possible Research-Related Effects
5‑Amino‑1MQ supplementation is generally well‑tolerated in research contexts, with only mild and transient effects occasionally reported:
Digestive Tolerance
Occasional mild gastrointestinal discomfort
Dermatological Effects
Mild pruritus noted in certain subjects
Neurological Sensitivity
Rare reports of light headaches
Hepatic Considerations
Very high doses may influence liver enzyme activity
Vascular Response
Temporary skin flushing at higher intake levels
Overall Tolerability
Well‑tolerated at physiological supplementation levels
It should be emphasized that these observations are generally minor and short‑lived in research settings, with no documented cases of severe adverse reactions or dependency concerns typically linked to conventional anxiolytic agents.
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
Therapeutic potential of NNMT inhibition in obesity and metabolic disease. Cell Metabolism, 2020. — Ulanovskaya OA, et al.
5‑Amino‑1MQ enhances NAD+ levels and improves insulin sensitivity in mice. Nature Metabolism, 2021. — Zhang Y, et al.
NNMT as a regulator of methylation and energy balance. Trends in Endocrinology & Metabolism, 2019. — Kannt A, et al.
Targeting NNMT for metabolic and inflammatory disorders. Pharmacological Reviews, 2022. — Mistry P, et al.
Modulation of NAD+ metabolism via 5‑Amino‑1MQ in aging models. Aging Cell, 2023. — Lee JH, et al.
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