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AOD9604

Description

AOD9604, known as "Anti-Obesity Drug 9604," stands out as a key achievement in targeted metabolic studies. Designed to capture solely the fat-releasing effects of human growth hormone, this peptide segment delivers focused lipid breakdown without the broader hormonal impacts of complete HGH. It's like pulling out only the "fat-reduction section" from the full spectrum of growth hormone activities.

AOD9604's appeal lies in its evolution from clinical trial prospect to GRAS-approved nutraceutical component. Even with varied trial outcomes, its outstanding safety record and distinctive mode of operation maintain its relevance in fat metabolism research, providing investigators a clean method to explore lipolysis free from full hormone-related challenges.

Additional Information

  • Weight: 0.08 lbs

  • Dimensions: 0.87 × 1.18 × 0.87 in

  • Size: 10mg

This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.

Highlights

Structural Properties

  • Appearance: White to slightly off-white freeze-dried powder

  • Solubility: Easily dissolves in water

  • Storage Conditions: Store refrigerated at 36–46 °F (2–8 °C)

  • Stability: Highly stable due to disulfide bond

Biochemical Profile

  • Chemical Formula: C₇₈H₁₂₃N₂₃O₂₃S₂

  • Molecular Weight: 1815.12 g/mol

  • Origin: HGH Fragment 176-191 + Tyrosine

  • Structure: Modified peptide with disulfide bridge

Biological Mechanism

AOD9604 utilizes a distinctive approach that specifically focuses on fat metabolism:

Key Mechanisms

Beta-3 Receptor Stimulation

Boosts receptors responsible for fat destruction and calorie burning

Fat Breakdown Activation

Converts accumulated fats into usable energy components

Fat Formation Blockade

Prevents development of new fat deposits and storage

Independent from HGH Pathway

Functions through proprietary mechanism, not hormone receptors

Metabolic Benefits

No IGF-1 Increase

Eliminates side effects linked to complete growth hormone

Blood Sugar Stable

Preserves normal glucose levels and insulin function

Precise Targeting

Affects only fat areas without hormone disruption

Research Highlights

Scientific and clinical studies have identified multiple uses for AOD9604:

Clinical Study Findings

Six human trials confirmed:

• Outstanding safety record with few adverse reactions

• 1.8-2.8kg body weight reduction over 12 weeks

• No immune system activation or antibodies

• No changes in IGF-1 levels or sugar processing

• Approved GRAS status for supplement applications

Fat Metabolism Effects

Lab investigations demonstrate focused action:

• Increased fat breakdown in storage tissues

• Decreased fat creation and deposit buildup

Muscle tissue protection maintained

No influence on hunger signals

Anti-inflammatory cardiovascular effects

Joint Support Potential

Preliminary studies show promise for:

• Osteoarthritis pain and symptom relief

• Cartilage repair capabilities

• Lower inflammation in joint tissues

• Improved movement in test animals

• Complements hyaluronic acid therapies

Heart Health Advantages

Research suggests benefits including:

• Optimized cholesterol patterns

• Lower heart disease indicators

• Improved blood vessel performance

• No negative heart impacts

Anti-inflammatory cardiovascular effects

Possible Research-Related Effects

AOD9604 is characterized by an outstanding tolerability profile:

Minimal Adverse Events

Consistently well‑tolerated across clinical evaluations.

Local Administration Effects

Occasional mild redness or irritation at injection sites observed.

Absence of Systemic Impact

No hormonal or metabolic disturbances reported.

No Antibody Formation

Studies show no immune response triggered.

GRAS Classification

Recognized as safe under established guidelines.

Extended Safety Record

Long‑term studies reveal no adverse outcomes.

The strong tolerability profile supports its GRAS recognition in nutraceutical applications.

Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.

References

Growth hormone secretagogues and metabolic effects: Focus on AOD9604. Metabolism, 2023.

Detection and in vitro metabolism of AOD9604. Drug Test Anal, 2016.

Peptide therapeutics for cartilage regeneration and osteoarthritis treatment. Front Pharmacol, 2022.

Anti-obesity drug discovery: advances and challenges in targeting metabolic pathways. Nat Rev Drug Discov, 2021.

Therapeutic peptides for fat loss: Current status and future directions. BioDrugs, 2020.

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