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Epithalon
Epithalon
$65.00
Epitalon
Quantity
Description
Epithalon, also referred to as Epitalon or Epitalone, is a synthetic tetrapeptide often likened to a cellular fountain of youth. First identified in the pineal gland, this short four–amino‑acid sequence has attracted international interest from researchers focused on longevity. Its notable appeal stems from evidence that it may act on aging processes at the chromosomal level, particularly by supporting telomere maintenance—the protective end caps of chromosomes that progressively shorten with age.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 50mg, 10mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Structural Properties
Appearance: White, freeze‑dried powder
Solubility: Easily soluble in water
Origin: Synthetic analogue of epitalamin
Storage Conditions: Store refrigerated at 2–8 °C (36–46 °F)
Biochemical Profile
Chemical Formula: C₁₄H₂₂N₄O₉
Molecular Weight: 390.34 g·mol
Amino Acid Sequence: Ala‑Glu‑Asp‑Gly
CAS Number: 307297‑39‑8
Biological Mechanism
Epithalon exerts its effects through a series of connected processes that target aging at a cellular level.
Core Mechanisms
Telomerase activation
May trigger telomerase activity, helping preserve or extend telomere length.
Melatonin modulation
Supports normalization of melatonin synthesis and alignment of circadian rhythms.
Antioxidant support
Strengthens cellular antioxidant defenses and lowers oxidative damage.
Cellular-Level Actions
Genomic protection
Contributes to maintenance of DNA integrity and genomic stability.
Mitochondrial support
Improves mitochondrial performance and cellular energy output.
Neuroendocrine regulation
Helps balance hormonal signaling across neuroendocrine pathways.
Research Highlights
Extensive research has demonstrated Epithalon’s wide‑ranging influence on various organ systems.
Anti‑Aging Actions
Research highlights notable longevity‑related outcomes:
• Lifespan extension observed in experimental models
• Favorable shifts in biological aging indicators
• Strengthened cellular repair and renewal capacity
• Slower progression of age‑associated decline
• Preservation of youthful gene activity patterns
Sleep and Circadian Regulation
Evidence points to significant improvements in sleep quality:
• Stabilization of melatonin secretion
• More balanced sleep stage distribution
• Enhanced synchronization of circadian rhythms
• Deeper and more restorative sleep phases
• Fewer age‑linked sleep disruptions
Neuroprotective Effects
Studies demonstrate protective actions on brain health:
• Better cognitive performance in aging subjects
• Defense against neurodegenerative changes
• Improved memory retention and learning ability
• Reduction of neuroinflammatory activity
• Sustained neural adaptability and plasticity
Cardiovascular Support
Findings suggest benefits for heart and vascular systems:
• Enhanced overall cardiovascular performance
• More stable blood pressure control
• Increased flexibility of blood vessels
• Lower oxidative burden in circulatory tissues
• Protection from age‑related cardiac alterations
Immune Function Modulation
Research indicates immune‑supportive properties:
• Recovery of T‑cell activity
• Stronger immune responsiveness in older models
• Greater resistance to infectious agents
• Balanced inflammatory signaling
• Improved immune monitoring and surveillance
Vision and Ocular Health
Evidence suggests positive impact on eye function:
Reduced progression of age‑related vision loss
Strengthened retinal performance
Lower incidence of cataract development
Better regulation of intraocular pressure
Possible Research-Related Effects
Epithalon shows strong safety characteristics, which enhance its relevance for studies on longevity.
Overall tolerance
Consistently well‑accepted in research settings
Absence of toxicity
No harmful effects detected, even at elevated dosages
Minor adverse events
Occasional, mild reactions at the site of administration
Drug compatibility
No meaningful interactions documented with other compounds
Extended use profile
Long‑term studies confirm continued safety over prolonged periods
Because DSIP is naturally present within the human body, it is associated with a reassuring safety profile
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
Epithalon peptide and telomerase activation in human cells. Khavinson VK. 2003
Epitalon’s impact on aging biomarkers and tumor incidence. Anisimov VN. 2003
Case study: biological age, telomeres, and cognition improvement. Phelan J. 2024
Pineal peptides and melatonin rhythm normalization. Korkushko OV. 2004
AEDG peptide stimulation of gene expression. Khavinson V. 2020
Restoration of hormonal balance via pineal peptides. Goncharova ND. 2005
Pineal and thymic peptides in human longevity. Khavinson VK, Morozov VG. 2003
Peptide bioregulation of aging: findings and future directions. Anisimov VN, Khavinson VK. 2010
Neuroprotective properties of EDR peptide. Khavinson V. 2021
Livagen peptide and age-related correction effects. Kozina LS. 2008
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