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GHK-Cu
GHK-CU
$65.00
Quantity
Description
The copper peptide GHK-Cu is considered one of the most sophisticated natural solutions for tissue repair and regeneration. Although small in size, its impact is remarkable: it was initially identified in human plasma and has since been shown to participate in multiple healing processes in the body.
What makes GHK-Cu particularly interesting is its ability to restore gene expression patterns to a more youthful state, influencing more than 4,000 human genes related to tissue repair, inflammation regulation, and antioxidant defense.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 50mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Structural Properties
Appearance: Blue-tinted powder crystals, the color originating from the presence of copper.
Solubility: Highly soluble in water.
Natural Occurrence: Naturally detected in human plasma, saliva, and urine.
Biochemical Profile
Chemical Formula: C₁₄H₂₁CuN₆O₄
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 100mg
CAS: 89030-95-5
Biological Mechanism
GHK-Cu acts as a signaling molecule, initiating and harmonizing diverse mechanisms of healing and restoration.
Core Mechanisms
Regulation of Gene Activity
Adjusts genetic expression patterns to encourage tissue recovery and minimize inflammation
Collagen Synthesis
Significantly enhances collagen production and supports better structural organization.
Copper Availability
Delivers accessible copper required for a wide range of enzymatic functions.
Growth Factor Stimulation
Encourages the release of growth factors essential for tissue regeneration.
Antioxidant Support
Strengthens the body’s innate antioxidant defenses.
Cellular-Level Actions
Stem Cell Recruitment
Draws stem cells to damaged areas and activates their repair functions.
Angiogenesis Promotion
Facilitates the formation of new blood vessels, improving nutrient delivery to tissues.
Clearance of Cellular Waste
Triggers mechanisms that eliminate defective proteins and cellular debris.
Barrier Integrity
Reinforces the skin’s protective barrier and enhances moisture retention.
Research Highlights
Scientific studies spanning several decades highlight the diverse applications and effects of GHK-Cu. Ongoing research has consistently revealed the multifaceted potential of GHK-Cu.
Skin Renewal and Anti-Aging
Research consistently demonstrates GHK-Cu’s capacity to counteract visible signs of skin aging.
• Gene Regulation: Influences the activity of more than 4,000 human genes.
• DNA Repair Genes: Enhances the expression of 47 genes involved in DNA repair.
• Expression Shifts: Roughly 31.2% of genes show changes of ≥50% in activity.
• Balance of Effects: About 59% of impacted genes are upregulated, while 41% are downregulated.
• Youthful Reset: Reprograms gene expression toward a younger biological state.
Collagen and Extracellular Matrix Support
Extensive studies highlight GHK-Cu’s broad impact on ECM components in experimental models.
• Collagen IV Boost: Increases synthesis by 25.4-fold when combined with hyaluronic acid (2023).
• Fibroblast Activity: Stimulates production of collagen types I and III, as well as elastin.
• Matrix Components: Promotes decorin and glycosaminoglycan synthesis.
• Enzyme Modulation: Regulates matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs).
• Structural Restoration: Helps recover ECM integrity in aged or photo-damaged skin.
Accelerated Wound Repair
Laboratory findings highlight GHK-Cu’s remarkable capacity to enhance wound healing.
• Faster Closure: Promotes rapid wound resolution in diabetic and ischemic models.
• Inflammation Control: Lowers TNF-β levels and reduces activity of metalloproteinases 2 and 9.
• Growth Factor Induction: Stimulates VEGF and fibroblast growth factor production.
• Keratinocyte Dynamics: Increases proliferation and migration of keratinocytes.
• Chronic Wounds: Improves recovery in persistent, non-healing lesions.
Anti-Inflammatory Activity
Research consistently shows GHK-Cu’s strong anti-inflammatory potential.
• Cytokine Reduction: Decreases IL-6 secretion triggered by TNF-α in fibroblasts.
• Pathway Suppression: Inhibits activation of the NFκB signaling cascade.
• Gene Expression: Downregulates pro-inflammatory cytokine activity.
• Oxidative Stress: Modulates markers linked to oxidative damage.
• Steroid Alternative: Demonstrates potential as a substitute for corticosteroids in experimental models.
Hair Regeneration Potential
Recent investigations suggest encouraging outcomes for applications in hair restoration.
• Follicle Enlargement: Demonstrated increase in hair follicle dimensions in experimental studies.
• Growth Cycle Extension: Lengthens the anagen (growth) phase of the hair cycle.
• Scalp Circulation: Improves biological markers linked to blood flow in the scalp.
• Alopecia Impact: Shows potential to counteract follicle miniaturization associated with androgenic alopecia.
Broad Anti-Aging Benefits
Scientific evidence points to systemic advantages across multiple physiological indicators.
• Endogenous Concentrations: Decline from ~200 ng/ml at age 20 to ~80 ng/ml by age 60.
• Skin Appearance: Reduction in fine lines and wrinkles.
• Complexion Quality: Enhances clarity and overall tone of the skin.
• Structural Proteins: Promotes increased synthesis of elastin and collagen.
• Skin Firmness: Demonstrates tightening effects on lax skin in research models.
Possible Research-Related Effects
GHK-Cu has demonstrated a strong record of safety within controlled laboratory investigations:
Topical Use
Minor Reactions: Infrequent cases of slight redness or mild irritation.
Allergic Potential
Hypersensitivity: Rare instances of allergic response have been observed.
Copper Considerations
Sensitivity Risk: Possible concern in individuals with copper intolerance.
Systemic Observations
Safety Profile: Research reports no notable adverse systemic effects.
The presence of GHK-Cu as a naturally occurring peptide in the human body supports its strong safety profile.
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation. Int J Cosmet Sci, 2023.
The potential of GHK as an anti-aging peptide. Aging Pathobiol Ther, 2022.
Biotinylated GHK complexes with antioxidant properties. Int J Mol Sci, 2020.
Regenerative and protective actions of GHK-Cu in light of new gene data. Int J Mol Sci, 2018.
Effect of copper tripeptide on hair growth mechanisms. Ann Dermatol, 2016.
GHK peptide modulation of cellular pathways in skin regeneration. Int J Mol Sci, 2015.
Mechanisms of peptides in preventing aged skin. Int J Cosmet Sci, 2009.
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