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MOTS-c
MOTS-c
$55.00
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Description
Think of MOTS‑c as a cellular energy strategist—a peptide originating from the mitochondria, the cell’s own power generators, designed to fine‑tune how energy is utilized and distributed. Much like an intelligent thermostat that adjusts your home’s climate for efficiency, MOTS‑c appears to help cells recalibrate their energy demands in real time, potentially enhancing metabolic performance and resilience to stress.
Identified only in recent years within peptide science, MOTS‑c represents a groundbreaking advance in uncovering how mitochondria communicate with the rest of the cell. This 16‑amino acid molecule has demonstrated impressive potential in laboratory settings, influencing key metabolic pathways, modulating cellular aging processes, and supporting overall energy equilibrium.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 5mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Structural Properties
Appearance: White to off‑white lyophilized powder
Solubility: Freely soluble in water
Storage Conditions: Refrigerate at 36–46 °F (2–8 °C)
Stability: Remains stable under recommended storage parameters
Biochemical Profile
Chemical Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight: 2174.6 g/mol
CAS Number: 1627580‑64‑6
Peptide Sequence: 16 amino acids
Biological Mechanism
MOTS‑c functions as a central regulator of cellular metabolism, initiating diverse pathways that enhance the efficiency of energy utilization. Originating within the mitochondria, this peptide is released into the cell and can circulate through the bloodstream, extending its influence beyond individual cells to impact metabolic processes across the entire body.
Core Mechanisms
AMPK Pathway Engagement
Functions as the cell’s energy sensor. Once AMPK is triggered, cells improve fat utilization and sustain healthy insulin responsiveness.
Metabolic Control
Supports glucose uptake from circulation and enhances energy efficiency across diverse cellular systems.
Secondary Actions
Gene Regulation Influence
Modulates genetic activity linked to metabolism and aging, potentially extending youthful cellular performance.
Integrated Approach
This multi‑layered mechanism positions MOTS‑c as a compelling focus in metabolic and longevity research.
Research Highlights
Laboratory studies have identified several domains in which MOTS‑c shows noteworthy promise for scientific exploration. Researchers have observed its potential to influence diverse metabolic processes, support cellular resilience, and contribute to broader investigations into energy regulation and longevity.
Metabolic Health Advancement
Laboratory findings highlight notable improvements in metabolic performance
• Exercise‑mimetic activity reported in 2024 investigations
• Enhanced insulin sensitivity via AMPK pathway activation
• Mitigation of cognitive decline in aging models (2023)
• Stimulation of mitochondrial biogenesis and oxidative efficiency
• Increased glucose uptake independent of insulin signaling
• Improved glycemic control in high‑fat diet studies
• Reduction of fat accumulation in experimental subjects
• Strong potential for applications in metabolic disorder research
Cellular Energy Optimization
Evidence points to strengthened mitochondrial function and elevated energy output.
• Promotes fatty acid utilization as an energy source
• Boosts ATP generation in treated cell populations
• Demonstrates improved endurance in animal research models
• Facilitates more efficient overall energy expenditure
Neuroprotective Potential
Recent studies highlight protective actions on neural cells.
• Defense against oxidative stress
• Mitigation of age‑related neuronal deterioration
• Enhanced cognitive performance in experimental models
• Reduction of neuroinflammatory markers
Longevity & Healthy Aging
Evidence suggests benefits for extending healthspan in research contexts.
• Lifespan extension observed in selected models
• Activation of genes linked to longevity pathways
• Increased resilience against cellular stressors
• Age‑related decline identified as a primary research focus
Cardiovascular Benefits
Early research points to protective effects within the cardiovascular system.
• Safeguards cardiac tissue against injury
• Lowers inflammatory responses in vascular structures
• Enhances contractile performance of heart muscle
• Improves measurable indicators of cardiovascular function
Possible Research-Related Effects
Recent investigations have documented very limited adverse outcomes linked to MOTS‑c in controlled laboratory environments. Nevertheless, as with any experimental peptide, diligent observation and adherence to monitoring protocols remain critical to ensure safe and reliable research practices.
Metabolic Oversight
Potential alterations in blood glucose warrant observation in diabetic research models.
Administration Outcomes
Animal studies have noted occasional mild reactions at injection sites.
Extended Considerations
Hypothetical long‑term metabolic adjustments remain an area requiring deeper investigation.
Compound Interactions
Current data on interactions with other agents or medications is limited.
The majority of current investigations have been carried out in cellular systems and animal models, while human trials remain at an early stage. It is therefore essential that researchers document all observed outcomes thoroughly throughout their studies to ensure reliable data collection and interpretation.
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
MOTS‑c: A mitochondrial‑encoded peptide in aging and disease. Ageing Res Rev, 2024.
Exercise‑mimetic properties of MOTS‑c in metabolism. J Mol Med, 2024.
MOTS‑c reduces insulin resistance and cognitive decline. Nat Commun, 2023.
Mitochondrial‑derived peptides in cardiovascular disease. Front Cell Dev Biol, 2023.
MOTS‑c is an exercise‑induced mitochondrial regulator of physical performance. Am J Physiol, 2021.
MOTS‑c: Novel mitochondrial‑derived peptide in muscle and fat metabolism. Front Endocrinol, 2019.
Mitochondrial‑derived peptides associated with aging and longevity. Nat Commun, 2018.
The mitochondrial‑derived peptide MOTS‑c promotes metabolic homeostasis. Cell Metab, 2015.
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