NAD+
NAD+
$119.00
Quantity
Description
Nicotinamide Adenine Dinucleotide (NAD+) is often described as one of the most essential tools in healthy aging research. Delivered in a 500-1000 mg supplemental form, NAD+ is designed to elevate cellular levels of NAD+, the coenzyme present in every living cell that fuels energy metabolism and DNA repair. Beyond powering cellular energy, NAD+ plays a role in gene regulation, immune defense, and the biological processes tied to aging. The recognition that NAD+ naturally declines with age has sparked intense scientific interest, and supplementation with NAD+ is being explored for its potential to support brain health, metabolic efficiency, and extended healthspan.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 500mg, 1000mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Structural Properties
Stability: Sensitive to light and heat
Solubility: Highly water‑soluble
Storage Conditions: Keep refrigerated at 36‑46 °F (2‑8 °C)
Form: White lyophilized powder
Biochemical Profile
Chemical Formula: C₂₁H₂₇N₇O₁₄P₂
Molecular Weight: 663.43 g/mol
CAS: 53‑84‑9
Structure: Dinucleotide
Biological Mechanism
NAD+ functions as a master regulator of cellular activity through multiple interconnected mechanisms:
Key Mechanisms
Redox Reactions
NAD+ elevates cellular NAD+ levels, enabling electron transfer in more than 400 enzymatic reactions.
Sirtuin Activation
Provides the fuel for sirtuins, the “longevity proteins” that orchestrate aging and stress‑response pathways.
PARP Activation
Supports DNA repair enzymes (PARPs), reinforcing genomic stability and cellular resilience.
Metabolic Benefits
Energy Metabolism
Essential for converting nutrients into ATP via glycolysis and the citric acid cycle.
Fatty Acid Oxidation
Critical for fat metabolism and oxidative phosphorylation, enhancing mitochondrial efficiency.
Calcium Signaling
Acts as a substrate for CD38, influencing calcium signaling and immune system communication.
Research Highlights
The research on NAD+ supplementation has revealed its profound impact on health and aging across multiple biological systems:
Longevity and Aging
• Extended lifespan in yeast, worms, and mice models
• Restoration of youthful cellular function
• Improved mitochondrial health with age
• Enhanced DNA repair capacity
• Reduced cellular senescence
• Protection against age‑related diseases
DNA Repair and Cancer Prevention
• Enhanced DNA damage repair
• Reduced mutation accumulation
• Protection against UV damage
• Improved chromosomal stability
• Potential cancer prevention properties
Metabolic Health
• Enhanced insulin sensitivity
• Improved glucose metabolism
• Better lipid profiles
• Increased metabolic flexibility
• Protection against metabolic syndrome
• Reduced inflammation markers
Immune Function
• Enhanced T‑cell function
• Better inflammatory regulation
• Improved response to infections
• Reduced chronic inflammation
• Better immune surveillance
Neuroprotection
• Protection against neurodegeneration
• Improved cognitive function
• Enhanced memory and learning
• Reduced risk of Alzheimer’s pathology
• Better neuronal energy metabolism
• Protection against stroke damage
Exercise Performance
• Enhanced mitochondrial biogenesis
• Improved muscle function
• Better exercise capacity
• Faster recovery times
• Increased endurance
Cardiovascular Benefits
• Improved cardiac function
• Enhanced blood vessel elasticity
• Protection against heart failure
• Reduced atherosclerosis
• Better blood pressure regulation
• Improved endothelial function
Possible Research-Related Effects
NAD+ supplementation is generally well‑tolerated in research contexts, though some observations have been reported:
Flushing
Temporary skin flushing at higher intake levels
Headache
Rare reports of light headaches
Gastrointestinal
Occasional mild gastrointestinal discomfort
Itching
Mild pruritus noted in certain subjects
Generally Safe
Well‑tolerated at physiological supplementation levels
Liver Concerns
Very high doses may influence liver enzyme activity
It should be emphasized that these observations are generally minor and short‑lived in research settings, with no documented cases of severe adverse reactions or dependency concerns typically linked to conventional anxiolytic agents.
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
Therapeutic targeting of NAD+ metabolism in mitochondrial disease. Cell, 2023. — Reiten OK, et al.
NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol, 2021. — Covarrubias AJ, et al.
NAD+ metabolism and cardiovascular diseases. Nature Cardiovascular Research, 2024. — Abdellatif M, et al.
NAD+ boosting reverses vascular aging in mice. Nature Aging, 2023. — Sharma A, et al.
NAD+ enhances mitochondrial function and longevity pathways. Science, 2024. — Li C, et al.
NAD+ and metabolic regulation of age-related proteostasis. Nature Metabolism, 2023. — Dall M, et al.
NAD+ in brain aging and neurodegenerative disorders. Cell Metab, 2019. — Lautrup S, et al.
Preclinical and clinical evidence of NAD+ precursors. Nat Aging, 2021. — Reiten OK, et al.
Sirtuins and NAD+ in the development and treatment of metabolic and cardiovascular diseases. Circ Res, 2018. — Kane AE, Sinclair DA.
NAD+ metabolism, stemness, the immune response, and cancer. Signal Transduct Target Ther, 2021. — Navas LE, Carnero A.
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All products offered by Zenergen are intended strictly for laboratory research purposes only. These compounds are not authorized for human or veterinary use and must be handled exclusively by qualified professionals in controlled research environments. They are not intended for diagnostic, therapeutic, or clinical applications. Statements made on this website have not been evaluated by the U.S. Food and Drug Administration.