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SEMAX
SEMAX
$50.00
Semax
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Description
Semax can be envisioned as a molecular key that helps unlock the brain’s organizational potential. Much like a skilled archivist optimizing a library, this peptide appears to enhance neuronal communication and provide protection against cellular stress. Derived from a fragment of the natural hormone ACTH, Semax has drawn scientific interest for its distinctive ability to support cognition without the overstimulation commonly associated with traditional enhancers.
What makes Semax especially compelling in research is its subtle yet versatile mode of action. Rather than simply accelerating brain activity like caffeine, it seems to foster the brain’s inherent growth and repair pathways. This multifaceted support has positioned Semax as a subject of ongoing investigation for cognitive enhancement, neuroprotection, and broader neurological applications.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 5mg, 10mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Structural Properties
Stability: Stable in lyophilized state
Solubility: Freely soluble in water
Storage Conditions: Store at 36‑46 °F (2‑8 °C)
Form: White to off‑white lyophilized powder
Biochemical Profile
Chemical Formula: C₃₈H₅₄N₁₂O₉
Molecular Weight: 826.92 g/mol
CAS: 80714‑61‑0
Sequence: Met‑Glu‑His‑Phe‑Pro‑Gly‑Pro
Biological Mechanism
Semax functions through multiple intriguing pathways that remain under active investigation. Central to its activity is the stimulation of two essential neurotrophic proteins: brain‑derived neurotrophic factor (BDNF) and nerve growth factor (NGF). These molecules act like nourishment for neurons, supporting their growth, survival, and the formation of new synaptic connections.
Key Mechanisms
Neurotrophin Stimulation
Elevates BDNF and NGF levels, fostering neuronal growth, survival, and synaptic connectivity
Neurotransmitter Regulation
Optimizes brain signaling by modulating serotonin and dopamine pathways, enhancing network efficiency
Metabolic Benefits
Antioxidant Activity
Neutralizes harmful free radicals, protecting neurons from oxidative stress and cellular damage
Cerebral Circulation
Promotes improved blood flow, ensuring optimal oxygen and nutrient delivery to brain tissue
Research Highlights
Experimental research has uncovered a range of potential applications for Semax within diverse neurological fields:
Cognitive Performance Support
Studies suggest Semax may enhance several aspects of cognitive function, including memory consolidation, sustained attention, and mental clarity. Researchers have observed improved learning capacity and more efficient information processing in laboratory models.
Neuronal Safeguarding
Evidence indicates Semax may protect brain cells from multiple forms of damage. It appears to reduce beta‑amyloid accumulation (a hallmark of Alzheimer’s disease) and shield neurons from oxidative stress. This protective profile has made it a focus of neurodegenerative research.
Emotional Balance
Through modulation of serotonin and dopamine systems, Semax demonstrates potential for stabilizing mood and improving stress resilience. Findings suggest it may regulate emotional responses without the sedative effects often associated with conventional mood agents.
Post‑Stroke Rehabilitation
One of the most promising areas of investigation is Semax’s role in recovery following stroke. Research indicates it may help limit brain injury and support restoration of lost functions by promoting neural plasticity and repair mechanisms.
Neuroinflammatory Modulation
Laboratory studies reveal Semax possesses anti‑inflammatory activity within the brain, potentially reducing neuroinflammation that contributes to a wide range of neurological conditions.
Possible Research-Related Effects
5‑Amino‑1MQ supplementation is generally well‑tolerated in research contexts, with only mild and transient effects occasionally reported:
Local Effects
Intranasal delivery can sometimes cause mild nasal irritation in research settings.
Immune Response
Potential allergic reactions have been noted in sensitive individuals.
Vestibular
Temporary episodes of dizziness may occur during administration.
Neurological
Occasional mild headaches have been reported in study participants.
It’s important to note that these effects are typically mild and transient in research observations. However, comprehensive long-term safety data is still being collected.
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
Semax affects copper-induced Aβ aggregation and amyloid formation. ACS Chem Neurosci, 2022. — Grieco SF, et al.
Novel insights into protective properties of Semax at transcriptome level. Genes, 2020. — Dergunova LV, et al.
Functional connectivity changes from Semax and Selank administration. Dokl Biol Sci, 2020. — Samotaeva IS, et al.
Semax affects immune and vascular gene expression in focal ischemia. BMC Genomics, 2014. — Medvedeva EV, et al.
Semax action on AMPA receptor currents in Purkinje cells. Bull Exp Biol Med, 2015. — Kolomin T, et al.
Effects of Semax on global brain ischemia. Unpublished study, year not specified.
Semax and its Pro-Gly-Pro fragment in brain plasticity. Unpublished study, year not specified.
The heptapeptide Semax stimulates BDNF expression. Unpublished study, year not specified.
Antioxidant and antiamnesic effects of Semax. Unpublished study, year not specified.
Clinical evaluation of Semax in treatment of neurological diseases. Unpublished study, year not specified.
Neurotrophin-based therapeutics for brain disorders: BDNF modulation strategies. Expert Opin Drug Discov, 2024. — Mendez-David I, et al.
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