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VIP
VIP
$100.00
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Description
VIP emerges as a promising peptide in neuroendocrine and gastrointestinal research. Acting on vasoactive intestinal peptide pathways under investigation, it supports optimal smooth muscle relaxation, nutrient absorption, and systemic homeostasis. By engaging VPAC receptors and modulating cyclic AMP signaling, VIP contributes to improved gastrointestinal function, balanced immune responses, and protection against stress‑induced dysregulation.
Additional Information
Weight: 0.08 lbs
Dimensions: 0.87 × 1.18 × 0.87 in
Size: 5mg, 10mg
This product is intended solely for research purposes. It is not authorized for use in humans or animals and should only be handled by trained personnel in appropriate laboratory settings.
Highlights
Biochemical Profile
Stability :Stable under controlled laboratory conditions
Solubility: Readily soluble in aqueous buffers
Storage Conditions: Store at −20 °C in lyophilized form
Form: Synthetic peptide, typically supplied as a lyophilized powder for reconstitution in sterile aqueous solution.
Structural Properties
Amino acid sequence: His‑Ser‑Asp‑Ala‑Val‑Phe‑Thr‑Asp‑Asn‑Tyr‑Thr‑Arg‑Leu‑Arg‑Lys‑Gln‑Met‑Ala‑Val‑Lys‑Lys‑Tyr‑Leu‑Asn‑Ser‑Ile‑Leu‑Asn
Molecular Mass: ~3,326 g/mol
Composition: C₁₄₉H₂₂₉N₄₇O₄₂S
Architecture: Linear polypeptide of 28 amino acids
Biological Mechanism
VIP functions as a synthetic 28‑amino acid neuropeptide (His‑Ser‑Asp‑Ala‑Val‑Phe‑Thr‑Asp‑Asn‑Tyr‑Thr‑Arg‑Leu‑Arg‑Lys‑Gln‑Met‑Ala‑Val‑Lys‑Lys‑Tyr‑Leu‑Asn‑Ser‑Ile‑Leu‑Asn), engaging neuroendocrine and gastrointestinal regulatory pathways to support systemic homeostasis and optimize physiological performance.
Key Mechanisms
Neuroendocrine Regulation
VIP engages VPAC receptors in the central and peripheral nervous system, modulating cyclic AMP signaling to balance hormonal release and systemic homeostasis.
Smooth Muscle Relaxation
Promotes vasodilation and relaxation of gastrointestinal and respiratory smooth muscle, supporting circulation and airway function.
Gastrointestinal Function
Enhances nutrient absorption and digestive efficiency by stimulating intestinal secretions and motility.
Immune Modulation
Acts as an anti‑inflammatory mediator, regulating cytokine activity and protecting against stress‑induced dysregulation.
Metabolic Benefits
Energy Balance
VIP modulates cyclic AMP signaling to optimize cellular energy utilization and systemic metabolic stability.
Glucose Regulation
Supports insulin secretion and glucose homeostasis, contributing to balanced blood sugar control.
Digestive Efficiency
Enhances intestinal secretions and nutrient absorption, reinforcing gastrointestinal metabolism and nutrient availability.
Adaptive Resilience
Protects against stress‑induced metabolic dysregulation by stabilizing neuroendocrine and immune pathways.
Research Highlights
VIP demonstrates favorable tolerability in investigative research settings, with only mild and transient effects occasionally observed.
Neuroendocrine Pathways
Research highlights VIP’s role in modulating hypothalamic and pituitary signaling, contributing to systemic homeostasis.
Gastrointestinal Function
Studies demonstrate enhanced intestinal secretions and nutrient absorption, reinforcing digestive efficiency and metabolic balance.
Immune Regulation
Investigations show VIP acting as an anti‑inflammatory mediator, stabilizing cytokine activity and protecting against stress‑induced dysregulation.
Vascular Dynamics
Findings indicate VIP promotes vasodilation and smooth muscle relaxation, supporting circulatory resilience and adaptive recovery.
Possible Research-Related Effects
VIP exhibits favorable tolerability in research contexts, with minor and short‑duration effects occasionally reported:
Favorable Tolerability
VIP has generally shown good tolerability in investigative research, with most effects being mild and short‑lived.
Transient Vascular Sensations
Occasional brief flushing or warmth linked to vasodilatory activity, typically resolving without intervention.
Digestive Adjustments
Temporary gastrointestinal discomfort, such as mild bloating or changes in digestion, has been observed during metabolic adaptation phases.
Immune Modulation Effects
Minor shifts in cytokine activity occasionally observed, generally self‑limiting and part of adaptive regulation.
It’s important to note that these effects are typically mild and transient in research observations. However, comprehensive long-term safety data is still being collected.
Important Information: This material is restricted to experimental laboratory work and must not be used in humans or animals.
References
Vasoactive Intestinal Peptide (VIP). Wikipedia, actualizado 2025. — General overview of structure, gene location, and physiological roles.
Vasoactive Intestinal Peptide (VIP). Springer Encyclopedia of Pathology, 2021. — Entry describing biochemical features, precursor molecule, and vasodilatory activity.
VIP — The Peptide Encyclopedia. Wikipep, 2024. — Summary of VIP’s regulatory functions across multiple organ systems.
Vasoactive Intestinal Polypeptide. UpToDate, 2023. — Clinical review of VIP as a neuropeptide, vasodilator, and regulator of smooth muscle and epithelial secretion.
Immunomodulation of Innate Immune Responses by VIP. Clinical and Experimental Immunology, 2009. — Research article on VIP’s therapeutic potential in inflammatory disease.
Emerging Roles of VIP: A New Approach for Immune Disorders. Annals of the Rheumatic Diseases, 2007. — Review highlighting VIP’s anti‑inflammatory and immunoregulatory potential.
Said & Mutt, 1970. Original Isolation of VIP from Porcine Duodenum. — Foundational study describing discovery and naming of VIP.
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